Study confirms risk of triple-negative breast cancer among obese, physically inactive women

February 04, 2016

Results showed that women with the highest BMI had a 35 percent increased risk of triple-negative breast cancers and a 39 percent increased risk of estrogen receptor-positive breast cancers. Those who reported high rates of physical activity had a 23 percent decreased risk of triple-negative breast cancer and a 15 percent decreased risk of estrogen receptor-positive breast cancer.

Amy Trentham-Dietz, Ph.D., an associate professor of population health sciences at the University of Wisconsin and an editorial board member of Cancer Epidemiology, Biomarkers & Prevention, said the study raises important questions.

"The body of literature, primarily meta-analyses, has shown most of the risk between obesity and breast cancer to be among the estrogen receptor-positive subtypes," she said. "This paper raises questions about the possible role of growth factors or inflammation, but these will need to be explored with larger patient groups with known breast cancer subtypes, especially triple-negative breast cancers."

SOURCE American Association for Cancer Research