Starving breast cancer cells of hedgehog significantly slows tumour growth and spread
April 17, 2016
"Finding an effective drug target for basal breast cancer is a very high priority. It is often referred to as 'triple negative disease', because it doesn't produce any of the oestrogen, progesterone or HER2 receptors, targets of the drugs tamoxifen and Herceptin, which are very effective in other breast cancers."
A/Prof O'Toole, also a pathologist at Sydney's Royal Prince Alfred Hospital, undertook the study as part of her PhD. "These findings may provide some hope to the many women who succumb to breast cancer each year, especially the basal sub-type, although obviously it is early days," she said.
"More work in animal models is needed to understand exactly how best to block this pathway."
"Our study demonstrates that starving breast cancer cells of hedgehog significantly slows their growth and spread."
Source: Research Australia