Researchers discover new mechanism by which BRCA1 gene mutations can induce breast cancer

March 20, 2016

BRCA1 acts on two levels, firstly, on the amount of progesterone receptor found in cells and, secondly, by controlling the expression of the progesterone genes.These findings demonstrate the direct relationship between an excess of the cellular effects of progesterone and the risk of developing breast cancer. The knowledge of the way the BRCA1 gene acts enables an understanding of its importance in the development of breast cancer and helps in designing improved therapies, which act directly on the molecules involved.In addition, the work of Veronica Calvo Miguel Beato and may have an influence at the level of cancer prevention. Just as when the direct relationship between oestrogen levels and the risk of developing breast cancer was demonstrated hormonal contraceptive methods were modified, perhaps the contribution of these researchers about the role of progesterone will also have repercussions for the prescription of contraceptive treatment.

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