Quality of life measures most useful for clinical decision-making in trials with QOL as primary outcome

December 19, 2015

They also write that when QOL is not the primary endpoint of a trial, "QOL results should ideally appear in a companion article published at the same time as the traditional medical outcomes article so that a full view of the risks and benefits of the intervention can be presented at the same time to clinicians."

In an accompanying editorial, Patricia A. Ganz, M.D., of UCLA, writes, "The large increase in the number of published studies identified in this high-quality systematic review reflects the increased acceptance of the patient's voice in assessing the outcome of trials as well as the participation of expert QOL investigators in the design, conduct, and analysis of clinical trials."

Ganz also writes, "Inclusion of well-validated measures of relevant symptoms should be a high priority for assessing the burden of breast cancer treatments, whether in survivors of breast cancer or in women with advanced disease receiving palliative care."

Source: Journal of the National Cancer Institute