Initial positive results from ZIOPHARM's ZIN-CTI-001 Phase Ib study against advanced melanoma

April 22, 2016

The study enrolled ten patients (median age 61) with unresectable Stage III or IV melanoma. Primary endpoints were safety and tolerability. Secondary endpoints included response, single dose and steady-state pharmacokinetics of the oral AL, an analysis of IL-12 and associated proteins, and cellular immune response (anti-melanoma and immunoregulatory cells) in blood and tissue biopsies. Patients were treated with autologous ZIN-CTI-001 cells (~ 5 x 10??) injected into accessible tumors, in combi...

Synta presents ganetespib Phase 1, 2 trial results against solid tumors at ASCO 2011

April 21, 2016

"Few therapeutic options are available to patients with advanced gastrointestinal tumors following treatment with the standard of care tyrosine-kinase inhibitor drugs, imatinib and sunitinib. Ganetespib showed activity in approximately half of GIST patients evaluated with PET imaging in this Phase 2 trial, including a 20% decrease in tumor metabolic activity," said George Demetri, M.D., Principal Investigator of the trial from the Dana-Farber Cancer Institute. "Analysis of tumor b...

APP to commence marketing Letrozole Tablets for breast cancer in the U.S.

April 20, 2016

Dr Strasser said this finding suggests that strategies for treating tumours by attacking the tumour blood supply could be optimised by incorporating drugs called BH3-mimetics that cause cell death by acting like Bim at a molecular level. "Similarly, therapies that increase the amount of Bim in tumour blood vessels could enhance the effects of anti-angiogenic agents," Dr Strasser said."BH3 mimetics may have two beneficial effects in cancer therapy. Our previous research had showed ...

NCIC CTG's exemestane clinical trial data on breast cancer presented at ASCO 2011

April 19, 2016

Vi Siemens and her three sisters have always been close and that relationship has been strengthened by their desire to do their part in preventing breast cancer. They have been participating in this landmark trial, sharing the daily bond of taking a pill and going for six-month check-ups. The sisters lost their mother and two aunts to breast cancer so are only too aware of the risk they face. But they did not hesitate in their decision to join the trial. "It wasn't a tough decision for me t...

U of A researchers try to combat heart disease in cancer patients

April 18, 2016

The pair will also try to detect if any of the women involved in the study have cardiac risk factors like high blood pressure and they'll try to treat those very aggressively. MANTICORE looks to enrol 139 patients, so far 15 are involved in Edmonton and the study is now adding centres in Winnipeg and Toronto. The study is being funded by the Alberta Cancer Foundation and Canadian Institutes of Health Research. Cardio-oncology is an emerging field of medicine and Paterson and Pituskin are leading...