Hunk protein inhibition might provide new approach to treat HER2-positive breast cancer

January 16, 2016

The researchers found that the use of bisphosphonates prior to diagnosis was strongly associated with a significant reduced relative risk for colorectal cancer - even after making adjustments for a large variety of known risk or protective factors for colorectal cancer such as family history, dietary components, physical activity, body mass index, and the use of other medications such as aspirin, statins and hormone replacement therapy.

"Bisphosphonates share the same mevalonate metabolic pathway as do statins, which we have previously shown to be associated with risk reduction of colorectal cancer," said Dr. Gruber. "This fact adds to the credibility of the current finding by adding biological plausibility."

Colorectal cancer is among the leading cancers in western countries, with more than 150,000 new cases diagnosed every year. In the U.S. alone, colorectal cancer kills some 50,000 deaths per year, making it one of the country's leading causes of cancer death.

"While the disease is generally caused by bad dietary habits and lack of physical activity, it can possibly be prevented by several medications, such as aspirin and cholesterol-lowering medication of the statins group," said Prof. Rennert. "And now, we can add bisphosphonates to the list of tools for potential prevention of colorectal cancer."

Source: Technion-Israel Institute of Technology