Genetic dermatology tests merge with DermaGenoma

January 06, 2016

Circulating tumor cells reducedCirculating tumor cells (CTCs) were strikingly reduced within 24 hours following PLX3397 treatment compared to vehicle. Recent literature shows that therapies that reduce CTCs improve patient survival. Primary tumors and metastases reducedPLX3397 treatment in a bone cancer model resulted in reduced tumor volume and invasion compared to the untreated cohort. Normal bone volumes maintainedPLX3397 treatment was shown to preserve normal bone volumes compared to significant bone destruction due to osteolytic cancer growth in the untreated cohort. Cancer-associated pain reducedPain levels were normalized with PLX3397 treatment compared with the untreated cohort. Cancer-related bone fractures preventedNo fractures were seen with PLX3397 treatment, whereas 100 percent of the untreated cohort experienced metastasis-related fractures. Primary tumors inhibited with combination treatmentA combination study with PLX3397 treatment and Taxol, a chemotherapeutic agent, showed a significant, synergistic anti-tumor effect in a breast cancer model.

"PLX3397 is an important component of Plexxikon's growing oncology franchise, as well as the lead candidate from our portfolio of highly selective Fms kinase inhibitors. We are excited about the potential to target mechanisms that drive disease progression, metastatic disease and bone pain experienced by cancer patients," stated K. Peter Hirth, Ph.D., chief executive officer of Plexxikon. "Early, but promising bio-response data from our Phase 1 trial has shown activity consistent with the preclinical data reported today. PLX3397 could represent an important first-in-class cancer treatment."

Rationale for PLX3397 as Treatment for Metastatic Cancers

PLX3397 selectively targets a number of cell types, including macrophages, microglia, osteoclasts and mast cells. These cells are involved in various aspects of tumor growth and metastasis. Growth factors for these cells are elevated in significant subsets of different human cancers (breast, colorectal, lung, glioblastoma, prostate cancers). These growth factors consequently activate these target cells leading to a microenvironment that supports tumor growth and also enables the tumor cells to escape into the blood stream and form metastases to distant sites, particularly to bone. Metastases to the bone can cause significant pain.

Source Plexxikon