Dosing initiated in combination Phase I study of palifosfamide with etoposide and cisplatin/carboplatin in SCLC

December 15, 2015

"The efficacy data and low toxicities observed with palifosfamide in clinical and preclinical studies together with the known activity of ifosfamide in SCLC provide strong rationale for studying palifosfamide in combination with the standard of care for this extraordinarily difficult to treat cancer," said Lawrence Einhorn, MD, Distinguished Professor at the Simon Cancer Center of Indiana University Medical Center, Lance Armstrong Foundation Chair in Oncology, former President of ASCO and a member of ZIOPHARM's Medical Advisory Board. "Small cell lung cancer in particular is a disease in urgent need of more effective and better tolerated treatment options."

According to the American Cancer society approximately 15 percent of lung cancers are SCLC, or approximately 33,400 patients yearly in the U.S. SCLC is almost exclusively associated with cigarette smoking and the majority of patients with extensive disease are treated front-line but relapse with a very high mortality within one year.

Source ZIOPHARM Oncology, Inc.