Boehringer Ingelheim commences afatinib Phase III clinical trial in advanced breast cancer

September 07, 2015

The initiation of the LUX-Breast 1 trial represents yet another important milestone for Boehringer Ingelheim to broaden and amplify its oncology development activities beyond lung cancer, again initiating the development of a potential novel agent for the treatment of an aggressive advanced cancer type.

Advancing Boehringer Ingelheim's oncology pipeline:

Afatinib is also being investigated for non-small cell lung cancer (NSCLC) in phase III clinical trials, the most common type of cancer. In the LUX-Lung clinical trial programme, one of the pivotal trials, LUX-Lung 3, evaluates the efficacy and safety of afatinib compared to standard chemotherapy (cisplatin/pemetrexed) as a potential first-line treatment of patients with locally advanced or metastatic NSCLC with EGFR mutation.In addition in another phase III trial, LUX-Lung 1, Boehringer Ingelheim investigates afatinib versus placebo in NSCLC patients after prior EGFR inhibitor therapy7.

Afatinib is just one of Boehringer Ingelheim's most advanced oncology pipeline compounds along with BIBF 1120, which is in phase III development for the treatment of patients with advanced NSCLC. Furthermore, in December 2009, Boehringer Ingelheim announced the initiation of its first pivotal phase III trial of BIBF 1120 in ovarian cancer.

The ongoing phase III development of its two most advanced compounds in a number of cancer types and patient populations. Continuously, Boehringer Ingelheim's oncology pipeline is evolving and demonstrates the company's continued commitment to the disease area.

SOURCE Boehringer Ingelheim