Acceleron presents RAP-661 preclinical data in osteopenic mice at international meeting
March 25, 2016
After six weeks of treatment, RAP-661 significantly increased trabecular bone (tibia) volume and cortical bone (femur) thickness compared to placebo in both OVX and sham-treated mice. Whole-body bone mineral density (BMD) as measured by DEXA after six weeks' treatment in OVX mice revealed that RAP-661 increased BMD from baseline by 14%, compared with increases of 14% for PTH, 7% for zoledronate, and 2% for placebo. In sham-treated mice with no bone loss, RAP-661 increased whole-body BMD by 12%, compared with increases of 9% for PTH, 8% for zoledronate and 1% for placebo. Bone mechanical strength was significantly increased in RAP-661 treated OVX mice. Histomorphometry and serum biomarker analysis showed an increase in osteoblast activity and a reduction in osteoclast activity, suggesting that RAP-661 has both anabolic and anti-resorptive effects.
"Over the past two decades, scientists and clinicians have recognized the important roles that BMPs play in the development and remodeling of bone," said Ravindra Kumar, PhD, Vice President of Cell Biology at Acceleron Pharma. "The rapid and significant increases in bone mass, volume and strength we observed with systemic administration of RAP-661 are remarkable. These results expand our understanding of bone biology and support the therapeutic potential for ACE-661 in patients with bone loss."
Source: Acceleron Pharma